A Brief Review on Pharmacological Effect of Some Phthalazine Derivatives on Cardiovascular and Kidney Functions

Phthalazine derivatives are biological potential compounds having diverse biological activities. In this review, briefly discuss about the effect of phthalazine derivatives on cardiac and kidney functions. A series of 4-(4-bromophenyl) phthalazine and phthalazinone analogs connected through 2-propanol spacer to N-substituted piperazine residue were tested for their effect on β-adrenergic blocking activity. Most compounds exhibited appreciable β-adrenolytic activity compared to propranolol. Compounds 1a, 1d, 1e and 2c showed appreciable inhibition of norepinephrine induced aortic ring contraction. Another series of phthalazine substituted urea and thiourea derivatives (5a–p) were tested for their inhibitory actions on the activity of human carbonic anhydrase (hCAs I and II) enzymes. All these compounds inhibited the CA isoenzymes activity. Compound 5a (IC50=6.40 M for hCA I and 6.13 Mfor hCA II) has the most inhibitory activity. Phthalazine derivatives were showed both β-adrenergic blocking and carbonic anhydrase activities and useful for both cardiac and kidney functions.